Our lab tackles some of the most significant challenges in treatment by investigating why cancers become resistant to therapy. Using powerful functional genetic screens, we identify the specific genes and cellular networks that allow tumors to survive, paving the way for new strategies to overcome drug resistance.

We also focus on cancers driven by mutations that are notoriously hard to treat. For these cases, we use an innovative approach called synthetic lethality to uncover a cancer cell’s unique ‘Achilles’ heel.’ By targeting these hidden vulnerabilities, we aim to develop highly specific, genotype-directed therapies that effectively eliminate cancer cells while leaving normal tissue unharmed.